Rapid Neuronal Ultrastructure Disruption and Recovery during Spreading Depolarization-Induced Cytotoxic Edema
نویسندگان
چکیده
منابع مشابه
Mechanisms of Neuronal Swelling during Spreading Depolarization
......................................................................................................................... ii Lay Summary ................................................................................................................ iii Preface .......................................................................................................................... iv Table of
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Hippocampal slices often have more synapses than perfusion-fixed hippocampus, but the cause of this synaptogenesis is unclear. Ultrastructural evidence for synaptogenic triggers during slice preparation was investigated in 21-day-old rats. Slices chopped under warm or chilled conditions and fixed after 0, 5, 25, 60, or 180 minutes of incubation in an interface chamber were compared with hippoca...
متن کاملExploitation of the spreading depolarization-induced cytotoxic edema for high-resolution, 3D mapping of its heterogeneous propagation paths.
Spreading depolarization (SD) is among themost archaic pathological phenomena of the central nervous system and already occurs in comparably primitive animals, such as locusts and cockroaches (1). SD describes a regenerative, all-or-none type of depolarization wave in gray matter of the central nervous system characterized by the abrupt, near-complete breakdown of the transneuronal ion gradient...
متن کاملIschemia-induced spreading depolarization in the retina.
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now ...
متن کاملSpreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke
Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures that only occurs under pathological conditions. In the present paper, we summarize the evidence from several decades of research that SD and cytotoxic edema in these structures are largely overlapping terms. SD/cytotoxic edema is a toxic state that - albeit initially reversible - leads eventually to cellula...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2020
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhaa134